Significant increase in biomass productivity needed to reach economic viability of algal production. Algal cultivation has great potential for recovery of nutrient and carbon resources from waste and side streams. Coupling wastewater treatment, remediation and reuse for biomass production contributes the circular bio-economy for improved resource management, in particular in arid environments. Microalgae that show robust performance under harsh conditions are also highly efficient in nutrient removal. Sustainability of algal cultivation can be improved by increasing the efficacy of production and, on the other hand, by selecting species which produce high-value compounds with health benefits for humans and animals. Moreover, algae produce a wide range of unique metabolites with features that can support and promote the production of plants and fish. Microalgae can be cultured by sustainable methods thus providing these metabolites from natural source with lesser environmental impact. This session will present different approaches to increase sustainability and efficacy of algal production and its application. It will discuss future perspectives and biotechnological applications of algae.